Almost 90 people in Harrow and Brent died from drug-related issues between 2016 and 2018, according to government statistics.
The latest figures showed 52 people in the region died from drug poisoning, while 37 died due to drug misuse.
More than 2,000 people in London suffered drug-related deaths during this timeframe, but the statistics were comparatively low in these north-west boroughs.
Harrow had the lowest number of drug poisoning deaths with 17, while only Merton and Kingston-upon-Thames had fewer drug misuse deaths.
The data in Brent was around average for the capital and Cllr Krupesh Hirani, responsible for public health at Brent Council, said it would always look to help those with drug issues.
He said: “We are working hard to prevent drug-related deaths by ensuring that any drug user who needs treatment can access services quickly and receive appropriate support.
“The New Beginnings Service, which is provided through a partnership of health and charity organisations and funded by the council, offers free and confidential support for individuals and their families affected by drug and alcohol problems in Brent.
“Everybody who uses the service receives a personalised support plan aimed at reducing harm, improving health and making people aware of what they can to do to support themselves and others to reduce drug related deaths.”
In Harrow, a video posted on social media last week appeared to show a suspected drug user passed out in a communal bin area.
A spokesperson for Harrow Council said: “We are aware of the issues at this estate relating to drug users who are not from the area. No one should ever feel unsafe where they live.
“We’re considering a number of options to help improve security and safety for the estate which includes using an outreach drug service and the assistance from the police.”
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